Hepatitis C virus (HCV) infection is one of the main causes ofchronic liver disease worldwide . The long-term hepaticimpact of HCV infection is highly variable, from minimal changesto chronic hepatitis, extensive fibrosis, and cirrhosis with or withouthepatocellular carcinoma (HCC). The number of chronicallyinfected persons worldwide may exceed 200 million, but mostof them have no knowledge of their infection or of the ensuinghepatic condition. Clinical care for patients with HCV-relatedliver disease has advanced considerably during the last two decades,as a result of growing knowledge about the mechanisms ofthe disease, remarkable developments in diagnostic procedures,and advances in therapeutic and preventative approaches. Still,various aspects are not yet completely resolved.
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